Which cell type is associated with lamellar bodies that store surfactant in the lungs?

Enhance your knowledge for the NBME Histology Test. Study with flashcards, multiple choice questions, hints, and explanations. Get exam-ready!

Multiple Choice

Which cell type is associated with lamellar bodies that store surfactant in the lungs?

Explanation:
Type II pneumocytes store surfactant in lamellar bodies. These cuboidal cells synthesize phospholipids and surfactant proteins, package them into lamellar bodies, and release them into the alveolar space by exocytosis. The surfactant coats the alveoli, lowering surface tension and preventing collapse during expiration. The other cell types don’t store surfactant: Type I pneumocytes are thin cells specialized for gas exchange and lack lamellar bodies; alveolar macrophages reside in the airspaces and help clear debris; and there is no ciliated alveolar epithelium.

Type II pneumocytes store surfactant in lamellar bodies. These cuboidal cells synthesize phospholipids and surfactant proteins, package them into lamellar bodies, and release them into the alveolar space by exocytosis. The surfactant coats the alveoli, lowering surface tension and preventing collapse during expiration. The other cell types don’t store surfactant: Type I pneumocytes are thin cells specialized for gas exchange and lack lamellar bodies; alveolar macrophages reside in the airspaces and help clear debris; and there is no ciliated alveolar epithelium.

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